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COQ7
The ''clk-1'' (''clock-1'') gene encodes an enzyme (demethoxyubiquinone monooxygenase) that is necessary for ubiquinone biosynthesis in the worm ''Caenorhabditis elegans'' and other eukaryotes. The mouse version of the gene is called ''mclk-1'' and the human, fruit fly and yeast homolog ''COQ7'' (coenzyme Q biosynthesis protein 7).〔〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10229 )〕 CLK-1 is not to be confused with the unrelated human protein CLK1 which plays a role in RNA splicing. == Structure ==
The protein has two repeats of approximately 90 amino acids, that contain two conserved motifs predicted to be important for coordination of iron. The structure and function of the gene are highly conserved among different species. The ''C. elegans'' protein contains 187 amino acid residues (20 kilodaltons), the human homolog 217 amino acid residues (24 kilodaltons, gene consisting of six exons spanning 11 kb and located on chromosome 16).
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